Nebulizers

Collison

The collison nebulizer has been the workhorse generator in infectious disease aerosol studies for decades (see references below).  Biaera’s modified collison nebulizer includes preinstalled quick release fittings for the compressed air supply and the aerosol outlet.  These fittings facilitate simple, reliable connection to the aerosol system without the use of tools or hose clamps.   When used with the polycarbonate precious fluids reservoir, this implementation is reliable, safe, and easy to use.

Mixing Tube

Biaera’s mixing tube is equipped with a snap ring quick release for connection to the collison.  The rigid construction allows the collison to hang from the end of the mixing tube without support from a clamp, ring stand, or lab jack.  In addition to making installation quick and easy, this feature frees the laboratory of unnecessary tools and instruments that limit freedom of movement in the workspace.

Collison InstalledCollison nebulizer with preinstalled quick release fittings, free hanging from Biaera’s aerosol mixing tube.

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DS Reed, L Smith, T Dunsmore, A Trichel, LA Ortiz, KS Cole, and E Barry, “Pneumonic Tularemia in Rabbits Resembles the Human Disease as Illustrated by Radiographic and Hematological Changes after Infection,” PLoS One 6(9): e24654. doi:10.1371/journal.pone.0024654 (2011).

KM Gustin, JA Belser, DA Wadford, MB Pearce, JM Katz, TM Tumpey, and TR Maines, “Influenza virus aerosol exposure and analytical system for ferrets,” Proceedings of the National Academy of Science, doi:10.1073/pnas.1100768108 (2011).

D Saini, GW Hopkins, C Chen, SA Seay, EM Click, S Lee, JM Hartings, and R Frothingham, “Sampling port for real-time analysis of bioaerosol in whole body exposure system for animal aerosol model development,” Journal of Pharmacological and Toxicological Methods 63:143 (2011).

A Nalca, VA Livingston, NL  Garza, EE Zumbrun, OM Frick, JL Chapman, and JM Hartings, “Experimental infection of Cynomologus Macaques (Macaca fascicularis) with aerosolized Monkeypox Virus,” PLoS One, 5:e12880 (2010).

CJ Roy, DS Reed, CW Wilhelmsen, JM Hartings, S Norris, and KE Steele, “Pathogenesis of aerosolized Eastern Equine Encephalitis infection in guinea pigs,” Virology Journal, 6:170 (2009).

HS Heine, J Bassett, L Miller, JM Hartings, BE Ivins, ML Pitt, D Fritz, SL Norris, and WR Byrne, “Determination of antibiotic efficacy against Bacillus anthracis in a mouse aerosol challenge model,” Antimicrobial Agents and Chemotherapy, 51:1373 (2007). 

JA Jeddeloh, DL Fritz, DM Waag, JM Hartings, and GP Andrews, “A bio-defense driven murine model of pneumonic melioidosis,” Infection and Immunity 71:584 (2003).

E Johnson, N Jaax, J White, and P Jahrling, “Lethal experimental infectious of rhesus monkeys by aerosolized Ebola virus,” International Journal of Experimental Pathology, 76(4):227 (1995).

EH Stephenson, RB Moeller, CG York, and HW Young, “Nose-only versus whole-body aerosol exposure for induction of upper respiratory infectious of laboratory mice,” American Industrial Hygiene Journal, 49:128 (1988).